association of adiponectin rs1501299 and rs266729 gene polymorphisms with nonalcoholic fatty liver disease

patients and methods eighty-three patients with diagnosis of nafld, and 93 healthy subjects were included in the study. tetra arms-pcr was designed to detect single nucleotide polymorphisms. results a significant difference was found between nafld and control group regarding the rs266729 polymorphism (χ2 = 7.35, p = 0.025). the rs266729 polymorphism increased the risk of nafld in codominant (cc vs. cg: or = 2.18, 95% ci = 1.16 - 4.12, p = 0.016) and dominant (cc vs. cg/gg: or = 2.31, 95% ci = 1.25 - 4.27; p = 0.008) inheritance tested models. the g allele increased the risk of nafld (or = 1.63, 95% ci = 1.03 - 2.57, p = 0.037) in comparison with c allele. no significant difference was found between the groups concerning adiponectin rs1501299 gene polymorphism (χ2 = 0.70, p = 0.697). background genetic and environmental factors are important for the development of nonalcoholic fatty liver disease (nafld). adiponectin is a white and brown adipose tissue hormone, and have been found to play essential roles in the regulation of energy homoeostasis. recent reports have identified a possible role of adiponectin in nafld via pparγ pathway. objectives the present study was designed to find out the impact of adiponectin rs1501299 (276g/t) and rs266729 (-11377c/g) gene polymorphisms in nafld. conclusions adiponectin rs266729 polymorphism might be a candidate gene, which determines the susceptibility to nafld. larger studies are necessary to confirm these findings in various populations.